pentobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers might increase the metabolism of ifosfamide to its active alkylating metabolites.

buprenorphine subdermal implant and pentobarbital the two boost sedation. Keep away from or Use Alternate Drug. Limit use to clients for whom substitute cure options are insufficient

Nursing mothers: Warning really should be exercised each time a barbiturate is administered into a nursing girl given that compact amounts of barbiturates are excreted during the milk.

pentobarbital will lessen the extent or impact of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If struggling to stay away from coadministration of stiripentol with robust CYP3A4 inducers, improve stiripentol dose.

In convulsive states, dosage of NEMBUTAL Sodium Alternative need to be held to a bare minimum to stay away from compounding the depression which may follow convulsions. The injection should be created slowly with because of regard to the time expected with the drug to penetrate the blood-Mind barrier.

pentobarbital will reduce the extent or result of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will decrease the extent or impact of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to a lower in fentanyl plasma concentrations, lack of efficacy or, quite possibly, growth of the withdrawal syndrome inside a affected person who's got designed Bodily dependence to fentanyl.

pentobarbital will reduce the extent or influence of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Effect of coadministering a robust CYP3A4 inducer with fedratinib has not been examined.

No studies have demonstrated that the different routes of administration are equivalent with regard to bioavailability.

pentobarbital will decrease the extent or effect of fosamprenavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will lower the extent or influence of capivasertib more info by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Strong or moderate CYP3A inducers decrease capivasertib publicity, which can cut down efficacy.

pentobarbital will lessen the extent or effect of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will minimize the level or impact of gefitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will decrease the extent or impact of apremilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration with robust CYP inducers ends in an important decrease of systemic publicity of apremilast, which may cause loss of efficacy